What happens when temperature and pH changes in native protein?

Hydrogen bonds are disturbed

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Globules unfold

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Helix uncoil

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Protein loses biological activity

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Solution

The correct option is D Protein loses biological activity
Protein found in biological system with unique 3D structure and biological activity is called native protein.

During denaturation, native protein may undergo physical change and chemical change.

Due to change in temperature and pH, the hydrogen bonds in the protein are disturbed and and globules gets unfold and helix starts to uncoil. Finally, the protein will loose its biological activity.

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