Question

What is a Ramchandran plot?

Answer 1

Ramachandran Plot:

1. Ramachandran Plot is a graph introduced by Dr. G.N. Ramachandran.
2. It is a space-filling model of peptides used to visualize energetically possible (i.e. sterically permitted) values for dihedral angles Ψ against Φ for a polypeptide chain.
3. The amino acid glycine occupies the maximum region in the graph because of its optical inactivity.
4. Whereas the imino acid, proline occupies the least area on the graph.
5. This graph was initially defined for parallel/antiparallel beta-sheets, left/right-handed alpha-helix, and collagen triple helix.
6. It is used in the analysis of the structure of a protein, and the conformation of amino acids found in the protein.
7. It is used to design proteinaceous drugs and artificial enzymes.