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What is Chargaff's rule?

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Chargaff's rule

  1. Chargaff's rules state that DNA from any cell of all organisms should have a 1:1 ratio (base Pair Rule) of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine.
  2. This rule is named for the great Austrian-American biochemist Erwin Chargaff (1905-2002) at Columbia University who discovered this rule.

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