Jacob's syndrome is a genetic disorder characterized by the presence of an extra Y chromosome.
It's a rare condition that affects one out of every 1000 male children.
Jacob's condition affects men who have 47 chromosomes, or XYY.
It happens when a sperm obtains an extra Y chromosome during meiosis II.
If non-disjunction happens during mitotic division during early embryonic development, mosaicism results, with some cells having regular chromosomes and others having an additional chromosome.
Jacob syndrome patients, for the most part, have normal lives with few defects.
Tall stature, weak muscles, learning impairments and speech problems, infertility, and so on are some of the symptoms.
Fertile individuals generate kids with a typical XY karyotype.