What is meant by crystallisation and what is the use of it?
Crystallization is one of the most widely used technologies in chemical industry, and process robustness governs process productivity and economics. In particular, the pharmaceutical and food sectors are utilizing crystallization for optimized separation, purification, and solid form selection. For example, crystallization is the most common method of formation of pharmaceutical solids for Active Pharmaceutical Ingredient (API) development. The optimization of the particulate properties such as particle size and shape distributions is paramount as the physical form dictates drug product quality and effectiveness.
Many pharmaceutical drugs have poor physiochemical profiles, such as poor solubility in biological fluids. Significant research and development efforts have been made towards developing a solid form landscape that covers all possible solid structures, including polymorphs, solvates, co-crystals, salts, and the amorphous phase to improve Active Pharmaceutical Ingredient (API) development.
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