Protoplasm is the living contents of a cell that is surrounded by a plasma membrane . It is a general term for the cytoplasm .[1] Protoplasm is composed of a mixture of small molecules such as ions , amino acids , monosaccharides and water , andmacromolecules such as nucleic acids , proteins , lipids and polysaccharides . [2] In eukaryotes the protoplasm surrounding the cell nucleus is known as the cytoplasm and that inside the nucleus as the nucleoplasm . In prokaryotes the material inside the plasma membrane is the bacterial cytoplasm, while in Gram-negative bacteria the region outside the plasma membrane but inside the outer membrane is the periplasm
The cytoplasm along with the cellular organelles is called protoplasm i.e., protoplasm = Cytoplasm + organelles or Protoplasm - Organelles =cytoplasm