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Chromosomes

What is the c...

Question

What is the cause for sickle-cell anemia?

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Solution

Sickle cell anaemia is caused by a mutant recessive allele on chromosome 11. That defective haemoglobin under goes polymerisation under law oxygen tension and changes the shape of RBC to sickle-shaped elongated cell.

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Read the passage and answer the following question.

The number of people in certain regions of Africa that suffer from sickle cell anemia is

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percent. This genetic disorder is caused by a mutation in which homozygous recessive results in sickle cell anemia, but in the heterozygote condition causes the sickle cell trait. The gene frequency for that allele and the percentage of people that are heterozygotes is

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