Question

What is the cause of senescence in cells such as human cells?

Answer 1

Senescence:

1. Senescence is the process of aging in humans.
2. Changes occurred in the structure of the telomere, a complex DNA–protein structure that caps the end of each chromosome, cause senescence in human cells.
3. Human cells, for example, lack telomerase, an enzyme that is responsible for telomere structure maintenance.
4. As a result, throughout the proliferation of these cells, telomeres gradually degrade until the DNA damage response system detects the damage and causes cell-cycle arrest.