What is the correct order in which the factors of clotting are affected in order for blood to clot?
What is the correct order in which the factors of clotting are affected in order for blood to clot?
The correct option is D Thromboplastin, Prothrombin, Thrombin, Fibrinogen, Fibrin
When the blood vessels are damaged, they attract platelets. The damaged endothelial cells express tissue factor. The tissue factor initiates a coagulation cascade. The end result of the cascade is the formation of an enzyme called prothrombinase. This prothrombinase cleaves prothrombin giving rise to thrombin.The platelets have specific thrombin receptors; the thrombin attaches to the platelets and forms a weak plate plug. Thrombin acts on fibrinogen in the plasma and cleaves it to form insoluble fibrin strands.The insoluble fibrin strands are then stabilized to form a clot by fibrin stabilizing factor which is also activated by thrombin.
Thromboplastin, Prothrombin, Thrombin, Fibrinogen, Fibrin
When the blood vessels are damaged, they attract platelets. The damaged endothelial cells express tissue factor. The tissue factor initiates a coagulation cascade. The end result of the cascade is the formation of an enzyme called prothrombinase. This prothrombinase cleaves prothrombin giving rise to thrombin.The platelets have specific thrombin receptors; the thrombin attaches to the platelets and forms a weak plate plug. Thrombin acts on fibrinogen in the plasma and cleaves it to form insoluble fibrin strands.The insoluble fibrin strands are then stabilized to form a clot by fibrin stabilizing factor which is also activated by thrombin.
