Actin filaments, usually in association with
myosin, are responsible for many types of cell movements. Myosin is the prototype of a
molecular motor—a protein that converts chemical energy in the form of ATP to mechanical energy, thus generating force and movement. The most striking variety of such movement is muscle contraction, which has provided the model for understanding
actin-
myosin interactions and the motor activity of myosin molecules. However, interactions of actin and myosin are responsible not only for muscle contraction but also for a variety of movements of nonmuscle cells, including cell division, so these interactions play a central role in cell biology. Moreover, the actin
cytoskeleton is responsible for the crawling movements of cells across a surface, which appear to be driven directly by actin polymerization as well as actin-myosin interactions.
Mitotic spindle is mainly composed of actin.
Spindles formed during mitosis and meiosis are nothing but microtubule complex. Microtubules are made up of small units of tubulin which has an amino acid composition similar to actin.
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