Question

What is the difference between Sertoli cells and Leydig Cells?

Answer 1

Sertoli cells:

1. Sertoli cells are testicular somatic cells that are required for testicular development and spermatogenesis.
2. Sertoli cells promote germ cell to spermatozoa development by direct interaction and by managing the ambient milieu within the seminiferous tubules.

Leydig Cells:

1. Leydig cells are necessary and critical cells found in the male gonads' testes.
2. Testicular interstitial cells are situated between seminiferous tubules, which contain Sertoli and germ cells.

Difference between Sertoli cells and Leydig Cells:

Sertoli cells	Leydig Cells
1. It is found specifically in the convoluted seminiferous tubules.	1. These cells are interstitial cells found in the testes near the seminiferous tubules.
2. Sertoli cells are also known as mother or nursing cells because they offer sustenance to growing sperms during spermatogenesis.	2. They produce testosterone, a male hormone that governs the maintenance of basic and secondary sexual characteristics in males.
3. Sertoli cells also function as phagocytes, consuming cytoplasm left over during spermatogenesis.	3. Steroid hormones known as androgens include testosterone, androstenedione, and dehydroepiandrosterone (DHEA).
4. Inhibin, ABP (Aromatase Binding Protein), and anti-mullerian hormone are all secreted by Sertoli cells.	4. The enzyme desmolase aggressively converts androstenedione and DHEA into testosterone.
5. They work together to produce the blood-testis barrier,' which prevents undesired molecules and pathogens from passing through.	5. Androgens are crucial in the development of secondary sexual characteristics throughout puberty, such as facial hair growth, sexual behavior, desire, and so on.