The systemic circulation provides nutrients, and other essential substances to the tissues and takes and other harmful substances away for elimination.
Aorta:
The first vessel of the systemic circulation is Aorta.
The oxygenated blood entering the aorta is carried by a network of arteries, arterioles, and capillaries to the tissues from where the deoxygenated blood is collected by a system of venules, veins, and vena cava and emptied into the right atrium.