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Question

Which is the largest enzyme in the human body?


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Solution

Enzymes:

  1. Our human body has many enzymes to perform different functions in different parts.
  2. Enzymes are catalysts with high proteinaceous compounds.
  3. These help in enhancing the rate of biochemical reactions that are taking place in our bodies. As proteins are made up of amino acids, enzymes are also the linear chains of amino acids.
  4. The largest enzyme present in the human body is Titin.

Titin:

  1. Reiji Natori 1954 first proposed an elastic structure (titin) in muscle fiber. Later in the year 1977, Koscak Maruyama and his co-workers isolated it from the muscle fiber as an elastic protein and thus called it Connection ( Titin).
  2. Its length is about 27,000 to 35,000 amino acids, that's why it is the largest enzyme.
  3. It is greater than 1µm in length and it functions as a molecular spring that is responsible for the passive elasticity of muscle.
  4. It is the third most abundant protein in muscle (after myosin and actin) and an adult human contains approximately 0.5 kg of titin.
  5. Titin is encoded by TTN Genes. TTN Genes provide instructions for making very large proteins.
  6. The titin protein is located between the myosin thick filament and the Z disk in the muscle fiber.
  7. Titin's primary functions are to stabilize the Myosin filament, center it between the thin Actin filaments, and to prevent overstretching of the sarcomere.
Thick filaments are anchored to Z disks by


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