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Question

What is the order of the decreasing reactivity for the carboxylic acid derivatives given above, in a nucleophilic substitution reaction?
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A
II, IV, I, III
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B
III, IV, I, II
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C
IV, I, II, III
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D
I, II, III, IV
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Solution

The correct option is A II, IV, I, III
Acid chloride is the most reactive followed by acid anhydride, then ester and amide is the most stable acid derivative. So, the order is as given above :

Hence, the correct option is A.

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