Different separation techniques are present depending on the property of the substances to be separated.
Centrifugation is a separation technique which uses the principle "density difference of the components".
When the mixture of components having different densities is rotated (or spun) using a centrifugal machine the denser particles are forced to move outward.
Milk is a colloid, where the fat globules are dispersed in the medium (water).
We can separate the cream from milk using the centrifugation technique.
The particles which are small in size (i.e., which cannot separate using ordinary filter paper) are separated using this process.
A simple centrifuge (in the laboratory) has a vertical shaft carrying four or more test tube holders where the mixture is put for rotation.
The centrifugal force acts on the particles which force denser particles to move outward and lighter particles to move towards the center.