We have 6 at the ones place of 246.
6 × 1 = 6
6 × 6 = 36
So, we could either have 1 or 6 at the ones place of the first number.
Let us check,
41 × 6 = 246
46 × 6 = 276
So, the first missing number is 1.
We have 2 at the ones place of 82.
We need to find 41 × ___ = 82
So, the second missing number is 2
82 ÷ 41 = 2
Product = 2 × 1 = 2
Thus, the product of the missing number is 2.