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Question

What is the purpose of C-peptide in proinsulin?

A
To extend the insulin molecule
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B
To bring A and B chain in correct orientation to form active insulin
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C
To remove N terminal signal peptide
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D
To bind to the glucose molecule
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Solution

The correct option is B To bring A and B chain in correct orientation to form active insulin
Proinsulin when produced naturally, has an N terminal signal peptide, A and B chain, and a C peptide. The C peptide is required for forming correct three dimensional structure of active insulin by bringing A and B chains in correct orientation. In the formation of mature insulin, the C peptide is edited out after disulphide linkages are formed between the A and B chains.

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