Question

What is the reaction catalyzed by complex IV?

Answer 1

The reaction of complex IV

1. Complex IV refers to a cytochrome c oxidase complex containing cytochromes a and a₃ and two copper centers.
2. It is a large transmembrane protein complex found in bacteria, archaea, and mitochondria of eukaryotes.
3. It is used to transfer electrons from cytochrome c to oxygen.
4. Four electrons are removed from four molecules of cytochrome c and transferred to molecular oxygen (O₂) and four protons, producing two molecules of water.
5. The process forms water and helps generate a proton gradient.
6. Then proton gradient coupled ATP synthesis.
7. It is considered one of the primary regulation spots for oxidative phosphorylation.
8. This enzyme is controlled by both genes of the nucleus and genes of mitochondria.
9. Cyanide can block complex IV.
10. Complex IV when blocked, electrons can no longer be transferred to oxygen, the final acceptor, and cellular respiration stops.