Question

What will be the percentage inheritance of a disorder from an x-linked diseased father to his son ?

(1)

0%

(2)

25%

(3)

50%

(4)

100%

Answer 1

1)0%
an affected father who has a mutation in a gene on the X chromosome can transmit either the X chromosome with this mutation or a Y chromosome to his children. If the mother is not affected or a carrier, none of his sons will be affected since they can only inherit a normal X chromosome from their mother and they inherit a Y chromosome from their father. Each daughter will have a 50% chance of being an unaffected carrier and a 50% chance of both X chromosomes being normal.