Question

What will happen if secretion of parietal cells of gastric glands is blocked?

• A. Gastric juice is deficient of pepsinogen
• B. Gastric juice is deficient of chymosin
• C. Deficiency of HCl leads to nonconversion of inactive pepsinogen into active pepsin
• D. Nonrelease of enterokinase from duodenal mucosa and non-conversion of trypsinogen into trypsin

Answer 1

Answer: (C)

Deficiency of HCl leads to nonconversion of inactive pepsinogen into active pepsin

Gastric glands are numerous microscopic tubular glands formed by the epithelium of stomach. The parietal cells (oxyntic cells) are large and most numerous on the sidewalls of gastric glands. They secrete hydrochloric acid and castle intrinsic factor. The peptic cells (zymogen) cells of gastric glands secrete gastric digestive enzymes as proenzymes-pepsinogen and prorennin and a small amount of gastric amylase and gastric lipase. The hydrochloric acid maintains a strongly acidic pH of about 1.5 to 2.5 in the stomach. HCl converts pepsinogen and prorennin to pepsin and rennin respectively.

So, the correct answer is 'Deficiency of HCl leads to nonconversion of inactive pepsinogen into active pepsin'.