Question

What will happen if the secretion of parietal cells of the gastric glands is blocked with an inhibitor?

• A. Gastric juice will be deficient in chymosin
• B. Gastric juice will be deficient in pepsinogen
• C. In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin
• D. Enterokinase will not be released from the doudenal mucosa and so, trypsinogen is not converted to trypsin

Answer 1

The correct option is C In the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin

Parietal cells are the stomach epithelial cells that secrete gastric acid (HCl) and intrinsic factor. Gastric HCl activates pepsinogen and converted into the pepsin that breaks the peptide bonds by a process known as proteolysis. So, in the absence of HCl secretion, inactive pepsinogen is not converted into the active enzyme pepsin.