Question

What would happen if number of centrioles will be increased per cell

Answer 1

The fact that the number of centrioles in interphase (two per cell) matches the number of spindle poles in mitosis suggests that centriole number determines the number of spindle poles. Consistent with this idea, supernumerary centrioles and multipolar spindles tend to co-occur in tumor cells . But if centriole number dictates spindle pole number, cells with supernumerary centrioles would fail in mitosis and thus could not contribute to tumor growth In some cases extraneous centrioles are seen to coalesce together into two clusters, one at each spindle pole implying that the effective number of microtubule organizing centers may not be directly proportional to the number of actual centriole pairs. In addition, cells have mechanisms to prevent re-duplication of centrioles as well as active error correction mechanisms to restore number following perturbation all of which appear designed to enforce a centriole copy number of two per cell.