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Question

When a nucleophile attacks a carbonyl compound, the one which is most reactive towards the nucleophile is:

A
CH3COCOC2H5
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B
CH3COCH2Cl
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C
4-Methoxybenzaldehyde
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D
CH3COCH2CH2Cl
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Solution

The correct option is A CH3COCOC2H5
As the nucleophilic attack on carbonyl carbon atom depends on the electrophilicity of the carbon atom. In (a), a strong withdrawing CO group is attached to carbonyl carbon atom so the elctrophilicity of the carbon atom is considerably increased.

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