The equivalent resistance of two resistors connected in series is the sum of the individual resistances.
We connect resistors in series so that a required value of resistance is obtained.
We cannot specify when to connect, but when the final resistance needed is of very high value, say 1000 ohm, we should connect the resistors in series rather than parallel.
We won't get very high value resistance by connecting them in parallel.
You know the difference in effective resistance. You have studied the equations.
So in such situation, where we need very high resistance, we connect them in series.