When the imidazole ring of Histidine is protonated, tendency of nitrogen to be protonated (proton migrates from −COOH) is in the order?
A
β > γ > α
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B
γ > β > α
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C
γ > α > β
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D
β > α > γ
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Solution
The correct option is Cγ > α > β γ(−NH2) is close to -COOH, in β(−NH−), the lone pair of electrons is involved in resonance, and the lone pair on α(−N=) is intact on N−atom. The order is : γ > α > β