Sub-mucosal glands (Brunner’s glands): The submucosal layer is formed of loose connective tissues containing nerves, blood and lymph vessels. In duodenum, glands are also present in sub-mucosa.
The intestinal mucosal epithelium has goblet cells which secrete mucus. The secretions of the brush border cells of the mucosa along with the secretions of the goblet cells constitute the intestinal juice or succusentericus. This juice contains a variety of enzymes like disaccharidase (e.g., maltase), dipeptidases, lipases, nucleosidases, etc. The mucus along with the bicarbonates from the pancreas protects the intestinal mucosa from acid as well as provide an alkaline medium (pH 7.8) for enzymatic activities. Sub-mucosal glands (Brunner’s glands) also help in this.