Which class of enzyme converts glucose – 6 – phosphate to fructose – 6 – phosphate?
Isomerases: Includes all enzymes catalysing inter-conversion of optical, geometric or positional isomers.
The second step of glycolysis involves the conversion of glucose-6-phosphate to fructose-6-phosphate. This reaction occurs with the help of the enzyme phosphoglucose isomerase. As the name of the enzyme suggests, this reaction involves an isomerization reaction.
The reaction involves the rearrangement of the carbon-oxygen bond to transform the six-membered ring into a five-membered ring. To rearrangement takes place when the six-membered ring opens and then closes in such a way that the first carbon becomes now external to the ring.