Question

Which hormonal deficiency is responsible for the following Cretinism.

Answer 1

The term cretinism related to severe hypothyroidism (deficiency of thyroid hormone) during birth resulted in stunted physical and mental growth. It is also known as congenital hypothyroidism, congenital Iodine-deficiency syndrome and salt deficiency syndrome.The main hormones secreted by the thyroid gland are thyroxine (T4) and triiodothyronine (T3). Hypothyroidism refers to an under active thyroid gland – meaning inappropriately low secretion of thyroid hormones – T4 and T3. Hypothyroidism in the newborn may result from absence of or abnormal development of the thyroid gland, destruction of the thyroid gland, failure of stimulation of the thyroid by the pituitary, and/or by defective or abnormal synthesis of thyroid hormones and thus results in cretinism.