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Question

Which is a base analogue?

A
5-Bromouracil
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B
Caffeine
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C
Colchicine
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D
Nitrous acid
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Solution

The correct option is C 5-Bromouracil
Base analogues are molecules that can substitute for normal bases in nucleic acids. Usually, substitution of a base analogue will result in altered base pairings and structural changes that affect DNA replication and transcription of genes.
5-Bromouracil is a brominated derivative of uracil that acts as a base analog, substituting for thymine in DNA, and can induce DNA mutation.

So, the correct answer is '5-Bromouracil'.

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