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B
Non-proteins
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C
Metal compounds
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D
Tightly bound to enzymes
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Solution
The correct option is A Proteins Many enzymes show enzymatic activity only in association with certain non protein substances. Such substances are known as cofactors. Cofactors may be simple ions such as magnesium or potassium ions or complex organic compounds. An organic non-protein cofactor which is easily separable from the enzyme is called coenzyme and the non-protein organic cofactor which is tightly bound to and non-dissociable from the enzyme is termed as prosthetic group. The organic cofactors directly reduce the activation energy and thus form a functional part of active site of enzyme. They act as carriers of chemical groups, atoms or electrons removed from the substrates during reactions.