Question

Which is the best evidence for lock and key theory (Template theory)?

• A. Feedback inhibition
• B. Competitive inhibition
• C. Allosteric competition
• D. Non-competitive inhibition

Answer 1

The correct option is B Competitive inhibition

Competitive inhibition

Due to structural similarity with the substrate, the inhibitor competes with the substrate for the active site of the enzyme and forms the enzyme inhibitor complex in competitive inhibition.

Thus, it prevents the enzyme action.
Examples include inhibition of succinate dehydrogenase by malonate which resembles succinate in structure.
It is the best evidence for the lock and key theory.
Final answer
(1) Competitive inhibition