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Question

Which is the correct order in which the proteins participate in clotting of blood?

A
Fibrinogen - Fibrin - Prothrombin - Thromboplastin - Thrombin
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B
Thromboplastin - Prothrombin- Thrombin - Fibrinogen - Fibrin
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C
Prothrombin - Thromboplastin - Thrombin - Fibrinogen - Fibrin
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D
Thrombin - Prothrombin - Thromboplastin - Fibrinogen - Fibrin
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Solution

The correct option is B Thromboplastin - Prothrombin- Thrombin - Fibrinogen - Fibrin
  • Blood clotting occurs following an injury or trauma. This is a mechanism to prevent excessive loss of blood from the body.
  • A clot is formed mainly of a network of threads, called fibrin.
  • An injury stimulates the platelets in the blood to release certain factors, which activate the mechanism of coagulation.
  • Platelets are a source of thromboplastin. Thromboplastinconverts prothrombin, which is a plasma protein that is formed in the liver, into the enzyme thrombin.
  • In turn, thrombin converts fibrinogen into fibrin. Fibrin is insoluble and forms the threads that bind the clot.
  • Thus, the correct answer is option B.

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