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Question

Which is the final component that enters the blood coagulation cascade?


A

Fibrin

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B

Fibrinogen

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C

Thrombin

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D

Prothrombin

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Solution

The correct option is A

Fibrin


Fibrin is an insoluble protein that is produced in response to bleeding and is the major component of the blood clot. It is a tough protein substance that is arranged in long fibrous chains and is formed from fibrinogen, a soluble protein that is produced by the liver and found in blood plasma.

When damage of tissues result in bleeding, fibrinogen is converted at the wound/injury into fibrin by the action of thrombin, a clotting enzyme. Fibrin molecules then combine to form long fibrin threads that entangle platelets, building up a spongy mass that gradually hardens and contracts to form the blood clot.This insoluble fibrin strands are then stabilized to form a clot by fibrin stabilizing factor.


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