Question

Which of the following agents does not cause contraction of the mesangial cells in the glomerulus?

• A. Noradrenaline
• B. Histamine
• C. Dopamine
• D. Vasopressin

Answer 1

The correct option is C Dopamine

Contraction of mesangial cells is coupled with the contraction of the basement membrane of the endothelium of glomerular capillaries. This causes a decrease in surface area of the basement membrane and thus a decreased glomerular filtration rate. Contraction can be caused by Ang-II, arginine vasopressin, endothelin-1, bradykinin, histamine, adenosine, serotonin, and thrombin. Isoproterenol and Dopamine attenuate the contraction of mesangial cells.

So, the correct answer is 'Dopamine'.