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Question

Which of the following alkyl halide is more reactive towards E2 reaction?

A
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B
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C
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D
CH3Cl
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Solution

The correct option is A
E2 is a bimolecular single step reaction proceeds through a transition state.
In this reaction, the base will abstract the proton and the leaving group leave the substrate which result in a partial double bond in the transition state.
The abstraction of a proton by a base and the departure of the leaving group occurs simultaneously. Hence, it is concerted reaction.
The rate of the reaction depend both on substrate and the base.
Substrate which gives more substituted alkene is the reactive one.
Compound (a) gives more substituted alkene which has two methyl group.
Compound (b) gives alkene with one substituted alkene
Compound (c) gives alkene with no methyl sustitutents
Compound (d) doesn't have a βcarbon so it does not undergo elimination rection.
Hence, the most reactive alkyl halide towards E2 is t-bulyl chloride


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