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Question
Which of the following amides will be most reactive toward Hoffmann- bromamide rearrangement?
Which of the following amides will be most reactive toward Hoffmann- bromamide rearrangement?
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Solution
The correct option is C
Reactivity of the substrate depends on electron donating power of the group. As methoxy group is more electron donating, (c) will be more reactive.
Reactivity of the substrate depends on electron donating power of the group. As methoxy group is more electron donating, (c) will be more reactive.
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