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Question

Which of the following amino acid has been solely regarded as a ketogenic amino acid?

A
Threonine
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B
Tyrosine
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C
Phenylalanine
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D
Leucine
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Solution

The correct option is A Leucine
The acetyl CoA, which is the precursor of ketone bodies is formed by the degradation of ketogenic amino acid. On the otherhand, glucogenic amino acids, are converted into glucose. Ketogenic amino acids are unable to be converted to glucose as both carbon atoms in the ketone body are ultimately degraded to carbon dioxide in the citric acid cycle. In humans, two ketogenic amino acids are lucine and lysine.

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