Which of the following amino acid residues is likely to be found on the inside of a water-soluble protein ?
A
His
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B
Asp
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C
Ile
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D
Arg
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Solution
The correct option is C Ile Histidine, aspartate and arginine are hydrophillic amino acids as they can easily form H-bonds with water. But isoleucine is hydrophobic amino acid which is normally buried inside the protein core and it tend to be repelled from water.