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Question

Which of the following amino acid residues is likely to be found on the inside of a water-soluble protein ?

A
His
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B
Asp
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C
Ile
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D
Arg
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Solution

The correct option is C Ile
Histidine, aspartate and arginine are hydrophillic amino acids as they can easily form H-bonds with water. But isoleucine is hydrophobic amino acid which is normally buried inside the protein core and it tend to be repelled from water.
So, the correct option is 'Ile'.

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