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Question

Which of the following best depicts how the sequential genetic information in a retrovirus is eventually translated into proteins?

A
DNA of retrovirus→ mRNA in host cells →Proteins
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B
RNA of retrovirus → DNA in host cell → RNA in host cell →Proteins
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C
DNA of retrovirus → tRNA in host cell → Proteins
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D
RNA of retrovirus → mRNA in host cell → Proteins
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Solution

The correct option is B RNA of retrovirus → DNA in host cell → RNA in host cell →Proteins
Genetic information in retrovirus has a different flow of information that is from RNA to DNA. This is made possible by enzyme reverse transcriptase. After the viral RNA genome converted to DNA, this DNA of viral genome integrates to host genome. On integration, host enzyme transcribes viral DNA into RNA and further translated into viral proteins. Hence, correct sequence is:
RNA of retrovirus → DNA in host cell → RNA in host cell →Proteins

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