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Question

Which of the following can be considered as the building blocks of chromatin in eukaryotes?

A
DNA and NHC
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B
DNA and NAPs
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C
DNA and histones
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D
RNA and NAPs
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Solution

The correct option is C DNA and histones
Chromosomes are the most condensed form of DNA found in eukaryotes. At the metaphase stage of the cell cycle, DNA is found in the form of chromosomes. It has 2 chromatid arms.

DNA strands wrap around histone proteins (8 histone molecules that constitute the histone octamer) to form a nucleosome. Chromatin is formed by repeating units of the nucleosome. Hence, chromatin is made up of DNA and histones.



Nucleosome → chromatin → solenoid → supercoil → chromatid → chromosome

The formation of chromatids involves another set of proteins that help in coiling and supercoiling, known as NHCs or non histone complexes. NHCs and histones are found in the eukaryotic nucleus.

NAP stands for nucleoid associated proteins. They are found in prokaryotes where they help in wrapping DNA and localisation of the prokaryotic genetic material in the nucleoid region. DNA forms large loops by wrapping around these proteins.

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