Which of the following causes increased aldosterone secretion?

Decreased blood volume

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Administration of an inhibitor of angiotensin-converting enzyme (ACE)

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Hyperosmolarity

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Hypokalaemia

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Solution

The correct option is A Decreased blood volume
Decreased blood volume stimulates the secretion of renin (because of decreased renal perfusion pressure) and initiates the renin–angiotensin–aldosterone cascade.

Angiotensin-converting enzyme (ACE) inhibitors block the cascade by decreasing the production of angiotensin II.

Hyperosmolarity stimulates antidiuretic hormone (ADH) (not aldosterone) secretion.

Hyperkalaemia, not hypokalaemia, directly stimulates aldosterone secretion by the adrenal cortex.

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