1
Question
Which of the following cell finally kills the target cell during hypersensitivity type IV reaction?
Which of the following cell finally kills the target cell during hypersensitivity type IV reaction?
Open in App
Solution
The correct option is B T killer cell
Type IV hypersensitivity also called delayed type hypersensitivity is a type of cell-mediated response. CD4+ helper T cells recognize antigen in a complex with Class II major histocompatibility complex. The antigen-presenting cells are macrophages that secrete IL-12. IL-12 stimulates the proliferation of CD4+ T helper cells. These cells secrete IL-2 and interferon gamma, further inducing the release of other Th cytokines, hence mediating the immune response. Activated CD8+ T killer cells then destroy target cells on contact. Thus the correct answer is option B.
Type IV hypersensitivity also called delayed type hypersensitivity is a type of cell-mediated response. CD4+ helper T cells recognize antigen in a complex with Class II major histocompatibility complex. The antigen-presenting cells are macrophages that secrete IL-12. IL-12 stimulates the proliferation of CD4+ T helper cells. These cells secrete IL-2 and interferon gamma, further inducing the release of other Th cytokines, hence mediating the immune response. Activated CD8+ T killer cells then destroy target cells on contact. Thus the correct answer is option B.
Suggest Corrections
0
Similar questions
View More
Join BYJU'S Learning Program
Explore more
Join BYJU'S Learning Program
