Question

Which of the following cell-surface proteins encoded by HLA is estimated before the transplant to prevent rejection?

• A. Immunoglobulins
• B. MHC
• C. APC
• D. All of the above

Answer 1

Answer: (B)

MHC

The correct answer is B (MHC)

Major histocompatibility complexes are protein molecules which present the antigen on the surface of the APC , There are two classes of MHC, MHC class I and MHC class II. MHC I is present on nucleated cells and it is different from individual to other, in human MHC are also Human Leukocyte Antigen.

So MHC or HLA typing must be done before organ transplant.