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Question

Which of the following characteristics make mice one of the best transgenic models?
I) Mice genome has been studied extensively
II) Their genome is similar to that of humans
III) They have long reproductive cycle like humans
IV) They are smaller in size

A
I, II only
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B
I, II and III
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C
II, III and IV
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D
I, II and IV
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Solution

The correct option is D I, II and IV
Animals that get their DNA manipulated to possess and express an extra (foreign) gene of interest are known as transgenic animals.

Mice have served as the most preferred transgenic animal models due to their high degree of similarity to humans in terms of their genetic makeup, physiology and anatomy.

Its genome has been fully sequenced and is being extensively studied.

Advantages of mice include their small size, ease of maintenance, short reproductive cycle and production of numerous offspring. They are also suitable for in vitro fertilisation and culture of embryos.


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