Question

Which of the following conversions involve ATP synthesis during glycolysis?

• A. Glucose$\to$Glucose-6-phosphate
• B. Fructose-6-phosphate$\to$Fructose-1,6-biphosphate
• C. 1,3-bisphosphoglyceric acid (BPGA) $\to$ 3-phosphoglyceric acid (PGA)
• D. All of these

Answer 1

Answer: (C)

1,3-bisphosphoglyceric acid (BPGA) $\to$ 3-phosphoglyceric acid (PGA)

In the energy conserving phase of glycolysis, the conversion of BPGA to PGA is catalyzed by phosphoglycerate kinase. The phosphate on carbon 1 is transferred to a molecule of ADP, yielding ATP and 3-phosphoglycerate. This type of ATP synthesis, traditionally referred to as substrate-level phosphorylation, involves the direct transfer of a phosphate group from a substrate molecule to ADP, to form ATP.
$1,3-bisphosphoglycerate+ADP\stackrel{Phosphoglyceratekinase}{\underset{{Mg}^{2+}}{\rightleftharpoons }}3-phosphoglycerate+ATP$