Which of the following correctly describes the function of RNase-H enzyme?

Causes RNA synthesis

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Causes activation of hnRNA

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Destruction of antisense nucleotide bounded mRNA

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Causes reverse transcription of RNA

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Solution

The correct option is C Destruction of antisense nucleotide bounded mRNA
Antisense agents inhibit the expression of a target gene in a sequence specific manner. Antisense oligonucleotides that are complementary to their target mRNA block translation of target mRNAs in a sequence specific manner, either by steric blocking of translation or by destruction of the bound mRNA via RNase-H enzyme. It cleaves the RNA moiety of a DNA-RNA heteroduplex and therefore leads to degradation of the target mRNA.

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