Question

Which of the following drugs is mainly used to treat enteric fever?

• A. Chloramphenicol
• B. Co-trimoxazole
• C. Ciprofloxacin
• D. All of the above

Answer 1

The correct option is D All of the above

• Chloramphenicol and co-trimoxazole are some of the drugs that were used earlier for treatment of typhoid fever/ enteric fever. They were used as the first line of treatment.
• Chloramphenicol is the class of antibiotics that interact with the ribosomes and prevent the elongation of the protein peptide chain in the bacteria.
  
• Ciprofloxacin treats by inhibiting the bacteria from growing any further by preventing the bacterial DNA strand from separating from one another for further replication.
• Co-trimoxazole is a combination of trimethoprim and sulfamethoxazole. This combination of dug is used to inhibit the folate synthesis in the bacterial cell. Tetrafolate is necessary for the production of essential amino acid which is used for the production of bacterial DNA.
• Some strains of typhoid bacterial have developed resistance against chloramphenicol and trimoxazole. For such cases, Ciprofloxacin is used.
• Therefore the answer option D is correct.