Question

Which of the following factors are involve in left shifting of oxygen dissociation curve?

• A. High ${PO}_2$ and low pH
• B. High ${PCO}_2$ and high $H^{+}$ concentration
• C. Low ${PO}_2$ and low temperature
• D. High ${PO}_2$ and low temperature

Answer 1

The correct option is C Low ${PO}_2$ and low temperature

The oxygen dissociation curve can be shifted right or left by a variety of factors. A left shift indicates increased oxygen affinity of hemoglobin allowing less oxygen to be available to the tissues(low pO2). A left shift is due to low temperature and low H+ concentration(high pH). It is a sign of hemoglobin's increased affinity for oxygen. So the left shifting is due to low pO2, low temperature, and high pH+.

So, Option 'C' is correct.