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Question

Which of the following genetic diseases results from a mutation that prevents protein dystrophin from forming?


A

Myasthenia gravis

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B

Duchenne muscular dystrophy

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C

Osteoporosis

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D

Rheumatoid Arthritis

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Solution

The correct option is B

Duchenne muscular dystrophy


Duchenne's muscular dystrophy is a genetic disorder seen on the X chromosome. It is due to a mutation in the gene that codes for a protein called Dystrophin which is an important structural component of muscle. Without muscles become weak, and eventually paralyzed. This disease affects primarily boys as they have only one X chromosome. Eventually, the disease affects the respiratory muscles and these boys die due to paralysis of respiratory muscles.


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