Question

Which of the following helps to design drugs?

• A. Genomics
• B. Proteomics
• C. Protein sequencing
• D. None of the above

Answer 1

Answer: (B)

Proteomics

Proteome refers to the entire complement of proteins produced by an organism including the modifications made to a particular set of proteins in the organism. Proteomics is a large-scale study of a specific proteome, including information on protein abundances, their variations, and modifications. Proteins constitute the majority of drug targets against which pharmaceutical drug design processes work. It involves studying interrelationships between proteins involved in health and disease and the necessary drug treatment. Proteomics contributes important insight that can be used to determine the pathophysiological basis for disease and to study the mechanism of drug action and toxicity. Online Mendelian Inheritance in Man also known as OMIM is an authoritative catalogue of human genes, genetic disorders and traits. It mainly focuses on gene phenotype relationship that is updated regularly and available freely. OMIM is a secondary database consists of data derived from the analysis of primary data such as sequences, active site residue of proteins and so on. Thus, the correct answer is option C.